宫外怀孕与移位植入窗口的风险增加有关:一项回顾性研究
Hong Zeng1,2, Yahan Chang1,2, Nenghui Liu3,4
1Department of Reproductive Medicine Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
BMC pregnancy and childbirth
|December 20, 2024
概括
宫外怀孕和晚期母亲年龄 (≥35岁) 显著增加了植入窗口 (WOI) 位移的风险. 了解这些因素对于改善辅助生殖技术中植入成功至关重要.
科学领域:
- 生殖医学 生殖医学
- 妇科 妇科 妇科 妇科
- 不孕症研究 不孕症研究
背景情况:
- 植入窗口 (WOI) 是成功植入胚胎的关键时期.
- 移位的WOI可以导致植入失败在辅助生殖技术 (ART).
- 识别WOI流离失所的风险因素对于优化生育治疗至关重要.
研究的目的:
- 评估与植入窗口 (WOI) 移位相关的风险因素.
- 评估子宫内膜受体检测 (ERT) 结果与WOI位移之间的关系.
- 为了确认有异胎妊娠史和WOI移位之间的关联.
主要方法:
- 对934名接受ART循环的患者进行了回顾性研究,至少有一次植入失败.
- 分析了3771个ART周期和2629个胚胎移植周期,使用了通用估计方程 (GEE) 模型.
- 使用通用添加模型 (GAM) 探索年龄,BMI和WOI位移之间的非线性关系.
主要成果:
- 60.17%的患者呈现受体阶段,39.40%的患者呈现受体前阶段,0.43%的患者呈现受体后阶段.
- 异胎妊娠史增加了62%的WOI位移风险 (aOR1.62,P=0.035). 异胎妊娠史增加了62%的WOI位移风险 (aOR 1.62,P=0.035).
- 年龄≥35岁的患者与<34岁 (aOR1.50,P=0.007) 患者相比,WOI位移的风险增加了50% (aOR1.50,P=0.007).
结论:
- 宫外怀孕和晚年母亲年龄 (≥35岁) 与增加WOI流离失所风险有显著联系.
- 初级不孕症和较高的BMI (≥22 kg/m2) 显示了增加WOI流离失所风险的趋势,尽管在统计学上并不显著.
- 这些发现突出了影响子宫内膜受体时间的关键人口因素,这些因素影响了不孕妇女的子宫内膜受体时间.
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