基于代谢综合征和社会人口统计特征预测前列腺癌风险的机器学习算法:一项前性队列研究
Tao Thi Tran1,2, Jeonghee Lee3, Junetae Kim1
1Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do, Republic of Korea.
BMC public health
|December 20, 2024
概括
机器学习有效地预测前列腺癌 (PCa) 风险,但代谢综合征 (MetS) 和其组成部分似乎不是显著的风险因素. 传统因素,如家庭病史,年龄和酒精消费,对于PCa预测至关重要.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 前列腺癌 (PCa) 的患病率正在上升,需要改进风险识别和预测模型.
- 代谢综合征 (MetS) 是一个日益关注的问题,其与PCa风险的潜在联系需要调查.
研究的目的:
- 使用机器学习 (ML) 选高风险PCa.
- 确定MetS及其组件是否与PCa风险增加有关.
主要方法:
- 一项针对41,837名韩国参与者的前性队列研究.
- 利用Cox比例危险和5个ML模型进行PCa预测.
- 使用综合障碍得分 (IBS) 和C指数评估模型性能.
主要成果:
- 所有模型都显示出良好的校准和区分 (C指数≥0.800,IBS=0.01).
- 除了MetS及其组件,模型性能得到了改善,生存支持矢量机实现了最高的C指数 (0.862).
- 一级家族PCa病史,酒精消费,年龄和收入是显著的预测因素.
结论:
- 在开发PCa生存预测模型时,ML模型是有效的.
- MetS及其组件似乎没有影响PCa易感性.
- 传统的风险因素,如家庭病史,年龄,酒精消费和收入在PCa预测中更有影响力.
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