饮食中的黄酸盐摄入量与加速衰老有负面关联:一项基于美国人口的横截面研究
Jintao Zhong1, Jiamin Fang1, Yixuan Wang2
1The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Nutrition journal
|December 20, 2024
概括
饮食中的黄素,包括黄和黄,与美国成年人生物衰老的减缓有关. 这些化合物以抗氧化和抗炎作用而闻名,显示出与降低PhenoAgeAccel的显著关联.
科学领域:
- 营养科学 营养科学
- 老年学是指老年学的学科.
- 生物化学 生物化学
背景情况:
- 黄类药物具有抗氧化和抗炎性质,表明潜在的抗衰老益处.
- 饮食中的黄类及其子类对衰老的特定影响仍在调查中.
- 这项研究旨在澄清饮食中的黄类素摄入量与生物衰老之间的关系.
研究的目的:
- 调查饮食中的黄酸盐摄入量与PhenoAgeAccel (生物衰老标志物) 之间的关联.
- 为了确定哪些亚类的黄类是最有效的缓解衰老.
- 探索剂量反应关系和这些影响的亚组差异.
主要方法:
- 利用了国家健康和营养检查调查 (NHANES) 三个周期 (2007-2018) 的数据.
- 采用加权线性回归,受限立方线 (RCS) 分析和加权量子总和 (WQS) 回归.
- 进行了多变量调整和子组分析以完善调查结果.
主要成果:
- 在饮食中总摄入的黄酸盐和PhenoAgeAccel之间观察到负相关性.
- 特定的子类,包括flavan-3-ols,flavanones,flavones和flavonols,显示出显著的负相关性.
- 黄被确定为黄混合物中主要有影响的成分 (52.72%);在几个子类中注意到非线性关系.
结论:
- 饮食中的黄酸盐摄入量与美国成年人加速衰老有负面关联.
- 黄,黄,黄-3-和黄是这种抗衰老效果的关键贡献者.
- 在没有慢性病和BMI较低的人群中,益处可能更明显.
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