2型糖尿病患者的肠道微生物群和超加工食品消费之间的关联:一个横截面研究
Takahiro Ichikawa1, Yoshitaka Hashimoto1,2, Yusuke Igarashi1
1Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-Ku, Kyoto, 602-8566, Japan.
Nutrition & metabolism
|December 20, 2024
概括
超加工食品的摄入与2型糖尿病患者的肠道细菌变化有关. 较高的摄入量显示与鲁米诺菌的反向联系和与罗斯布里亚的积极联系,影响肠道健康.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 代谢性疾病研究研究.
背景情况:
- 全球范围内,超加工食品 (UPF) 的消费量越来越大.
- 饮食模式显著影响肠道微生物群的组成.
- 2型糖尿病 (T2D) 与失生症有关,即肠道细菌的不平衡.
研究的目的:
- 研究2型糖尿病患者的UPF消费和肠道微生物群概况之间的关联.
- 在T2D队列中识别与UPF摄入密度相关的特定肠道细菌.
主要方法:
- 362名T2D患者的横截面研究.
- 使用饮食史问卷量化UPF消费量 (g/1000 kcal).
- 通过16S rRNA基因测序分析肠道微生物组成;使用相关性和多重回归分析探索关联.
主要成果:
- 在UPF的摄入密度与Bifidobacterium,Lactobacillus,Ruminococcus和Roseburia相关.
- 在对共变量进行调整后,Ruminococcus与UPF密度显示了适度的反相关性 (β = -0.11,p = 0.038).
- 罗斯布里亚与UPF密度呈现了适度的正相关性 (β = 0.12,p = 0.033).
结论:
- 在T2D患者中,UPF消费与鲁米诺菌有着适度的反向关联.
- 在T2D患者中,UPF消费与Roseburia有轻微的积极关联.
- 这些发现表明,UPF摄入量与T2D中的特定肠道微生物变化之间存在联系.
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