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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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与性疾病发作相关的边缘系统突触功能障碍.

Simote T Foliaki1, Bradley R Groveman2, Emmett A Dews2

  • 1Laboratory of Neurological Infections and Immunity, National Institute of Allergy and Infectious Diseases, Division of Intramural Research, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, MT, USA. simote.foliaki@nih.gov.

Acta neuropathologica communications
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概括

子疾病会扰乱边缘系统中的突触功能,影响认知和情绪. 海马体,下丘脑和杏仁体的早期突触损伤与疾病发病相关.

关键词:
认知 认知是一种认知.情绪 情绪 情绪 情绪边缘系统 边缘系统神经退行发生神经退行.普里翁病是普里翁病的一种疾病.突触传输是一种交互传输.

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科学领域:

  • 神经科学是一个神经科学.
  • 子生物学 子生物学
  • 突触生理学 突触生理学

背景情况:

  • 子疾病 (PrDs) 涉及错误折叠的子蛋白 (PrPC) 形成病态的子.
  • 临床症状包括认知衰退和情绪变化,与边缘系统有关.
  • 在PrDs期间的边缘区域的突触功能障碍是鲜为人知的.

研究的目的:

  • 研究子感染如何破坏海马体,下丘脑和杏仁体中的突触功能.
  • 在临床前和临床阶段,将突触功能障碍与认知和行为缺陷相关联.
  • 为了确定延迟PrD发病的潜在治疗点.

主要方法:

  • 研究了在临床前和临床早期阶段感染的小鼠.
  • 评估了特定边缘区域的突触功能,流量,神经元激发和神经振荡.
  • 分析了神经递质水平,突触囊泡循环和细胞骨完整性.

主要成果:

  • 在临床前,PrD导致调节失调,减少神经元发射,并减缓海马体,下丘脑和杏仁体的振荡.
  • 从临床上看,突触传输和可塑性受到显著干扰.
  • 观察到可溶性蛋白的耗尽,突触损失,异常的神经递质释放和细胞骨损伤.

结论:

  • 在临床前开始,病会在关键的边缘区域引起突触损伤.
  • 突触可塑性功能障碍与早期疾病症状相关,影响认知和情绪.
  • 针对早期的神经元功能障碍可能提供治疗策略,以延迟性疾病的临床发病.