婴儿养与儿童期多动症发展之间的关联:台湾的一项出生队列研究
Chiu-Ying Chen1,2, Pin-Yang Shih2, Chih-Ting Su3
1Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan.
Journal of child psychology and psychiatry, and allied disciplines
|December 21, 2024
概括
早期补充养,如大米固体,可以保护婴儿免受注意力缺陷/多动障碍 (ADHD) 的影响. 在本研究中控制其他风险因素后,母乳养的益处并不显著.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科卫生健康 儿科卫生健康
- 营养流行病学 营养流行病学
背景情况:
- 婴儿养习惯对于神经发育至关重要.
- 哺乳,补充养和ADHD风险之间存在潜在的联系,但需要有力的证据.
- 现有的研究通常依赖于横截面设计,限制因果推理.
研究的目的:
- 研究婴儿养与注意力缺陷/多动症障碍 (ADHD) 的发展之间的时间关系.
- 利用出生队列的纵向数据来检查这种关联.
- 为了确定可能影响ADHD风险的特定养模式.
主要方法:
- 使用台湾出生队列研究 (波I至IV) 的数据,采用了回顾性队列研究设计.
- 该研究包括19,721名参与者,他们拥有关于婴儿养,病史和ADHD发生情况的全面数据.
- 扩展的Cox模型与时间依赖的共变量被用来分析婴儿养和ADHD发病率之间的关联.
主要成果:
- 在54个月的时间里,ADHD的累积发病率为每1000人年5.56.
- 用大米固体食物补充养与ADHD风险降低有关 (HR=0.73).
- 增加ADHD风险的因素包括男性性别,低收入,低出生体重,孕产妇因素以及某些儿童/父母的医疗状况.
结论:
- 在最初的六个月内引入补充养对于保护婴儿免受ADHD的影响很重要.
- 当对其他变量进行调整时,在六个月内母乳养的保护作用在统计学上并不显著.
- 由于观察到的ADHD病例数量有限,建议进行较大的观察性研究,并延长随访期.
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