对卵巢储量下降和全身炎症标志物的评估
Seyedeh Shahed Shoarishoar1, Roya KaboodMehri2, Fereshteh Fakor3
1Gynecologist, Reproductive Health Research center, Department of Obstetrics & Gynecology, Al-zahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.. awa198011@gmail.com.
Cellular and molecular biology (Noisy-le-Grand, France)
|December 21, 2024
概括
卵巢储备减少与年龄和更高的卵泡刺激激素 (FSH) 水平有关,但不是全身炎症标志物. 这项研究调查了寻求生育治疗的不孕妇女的这些因素.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症研究 不孕症研究
- 临床诊断 临床诊断 临床诊断
背景情况:
- 卵巢储备评估对于不育妇女至关重要.
- 现有的诊断测试有其局限性.
- 有限的研究存在于炎症标志物和减少的卵巢储备.
研究的目的:
- 研究不孕妇女的全身炎症标志物和卵巢储备减少 (DOR) 之间的关系.
- 为了确定DOR的预测变量.
- 为了比较正常和减少卵巢储备的妇女之间的人口统计和实验室数据.
主要方法:
- 在阿尔扎哈拉医院生育诊所对174名不育患者进行横截面分析研究.
- 根据抗穆勒尔激素 (AMH) 水平 (>1.1 ng/ml与<1.1 ng/ml) 分类的患者.
- 年龄,BMI,均值,中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),红细胞分布宽度与血小板的比率 (RPR) 和卵泡刺激激素 (FSH) 的组间比较.
主要成果:
- 观察到年龄和BMI的显著差异;DOR组的平均年龄和BMI较高.
- 毛囊刺激激素 (FSH) 水平在DOR组显著更高.
- 在DOR和炎症标志物 (NLR,PLR,RPR) 之间没有发现显著的关联.
结论:
- 年龄和FSH水平是卵巢储备减少的独立预测因素.
- 系统性炎症标志物 (NLR,PLR,RPR) 在这个队列中与DOR没有显著的关联.
- 年龄是与卵巢储备减少相关的主要因素.
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