在单细胞分辨率上了解COVID-19宿主免疫力
Supratim Ghosh1,2, Ankita Chatterjee1,3, Arindam Maitra1
1Biotechnology Research and Innovation Council - National Institute of Biomedical Genomics, Kalyani, India.
International reviews of immunology
|December 21, 2024
概括
主体免疫力可以抵抗COVID-19. 本综述详细介绍了单细胞研究如何揭示SARS-CoV-2感染和接种疫苗期间免疫细胞的变化,从而有助于向治疗.
科学领域:
- 免疫学和病毒学
- 基因组学和生物信息学
背景情况:
- 宿主免疫反应对于对抗COVID-19至关重要.
- 单细胞转录组学提供了对抗SARS-CoV-2免疫的细胞和分子机制的高分辨率洞察.
- 了解免疫细胞动态对于开发有效的COVID-19治疗非常重要.
研究的目的:
- 系统地审查对宿主免疫反应对SARS-CoV-2感染和疫苗接种的单细胞转录学研究.
- 描述病毒引起的免疫细胞丰度和分子行为的失调.
- 为了确定与COVID-19相关的特定免疫细胞种群,用于治疗向.
主要方法:
- 在过去3-4年中发表的单细胞转录组研究的系统审查.
- 在COVID-19患者和接种疫苗的人群中分析免疫细胞类型和状态.
- 在先天性和适应性免疫中细胞和分子变化的表征.
主要成果:
- 详细描述SARS-CoV-2诱导的免疫细胞群和状态的变化.
- 洞察免疫细胞在感染和疫苗接种后的分子行为.
- 鉴定与COVID-19病原体相关的特定不受调节的免疫细胞子集.
结论:
- 单细胞转录组学提供了COVID-19中免疫失调的高分辨率视图.
- 与疾病相关的免疫细胞的特征可以告知有针对性的治疗方法的开发.
- 对这些特定细胞群的进一步研究可能会导致改善治疗策略.
相关概念视频
01:27Cytotoxic T Cells-mediated Immune Response
844
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
844
01:23Cells of the Adaptive Immune Response
956
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
956