坦桑尼亚桑给巴尔的乙型肝炎护理和治疗:根据2015年世卫组织治疗指南,2017-2021年的示范项目
Sanaa S Said1,2, Shaun Shadaker3, Brian J McMahon4
1The State University of Zanzibar, Zanzibar, Tanzania.
Journal of viral hepatitis
|December 21, 2024
概括
桑给巴尔的一项乙型肝炎示范项目表明,在资源乏的环境中,护理和治疗是可行的. 该计划成功地降低了病毒载量,并改善了接受特诺福维尔二二 fumarate (TDF) 的参与者的肝脏健康标志物.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 乙型肝炎病毒 (HBV) 感染影响了桑给巴尔3.6%的人口.
- 实施了一项为期5年的示范项目,以评估HBV护理和治疗可行性.
- 该项目遵循了2015年世界卫生组织 (WHO) 的HBV护理和治疗指南.
研究的目的:
- 评估在资源较少的环境中实施乙型肝炎护理和治疗计划的可行性.
- 评估治疗对HBV感染个体的临床和实验室结果的影响.
- 确定成功管理HBV的关键挑战和关键组件.
主要方法:
- 招募596名成年人 (≥18岁) 呈HBV表面抗原阳性,呈HIV/C型肝炎阴性.
- 为符合条件的参与者免费提供特诺福维尔二氧化 (TDF).
- 在基线和每6-12个月监测临床症状,肝病和实验室标记 (ALT,APRI,HBV DNA).
主要成果:
- 268名参与者 (45%) 完成了至少一次随访.
- 58名患者根据肝硬化,APRI评分,HBV DNA水平或ALT活性开始治疗.
- 接受治疗的患者显示ALT活动,APRI得分和HBV DNA水平显著降低.
结论:
- 乙型肝炎的护理和治疗计划在资源较少的环境中证明了可行性.
- 检测和与护理的联系对于减少全球乙型肝炎的负担至关重要.
- 该项目强调了像TDF这样的可访问的治疗选择的重要性.
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