相关实验视频

Updated: Jun 4, 2025

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes

Published on: March 12, 2013

慢性病与三级心房阻塞之间的关联:丹麦全国性研究

Hannah K Wood-Kurland¹, Anne Storgaard Nørskov², Nicholas Carlson³

¹Department of Cardiology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Department of Cardiology, North Zealand Hospital, Hillerød, Denmark; Royal Library, Copenhagen University Library Incl. UH, Copenhagen, Denmark.

JACC. Clinical electrophysiology

|December 21, 2024

概括

慢性病 (CKD) 与第三级心房静脉阻塞 (3AVB) 的更高风险有关. 这种关联在接受透析的患者中特别强烈,突出显示了脏健康和心律之间的关键联系.

科学领域:

心脏病学心脏病学
腎臟病學 (nephrology) 是一種醫學.
流行病学流行病学

背景情况:

慢性病 (CKD) 与心律失常的增加和心脏突然死亡有关.
慢性病与三级心房阻塞 (3AVB) 之间的特定关系仍未得到充分研究.

研究的目的:

调查慢性病 (CKD) 与第三级心房阻塞 (3AVB) 的发生之间的关联.

主要方法:

一项基于人口的嵌套病例控制研究,利用1995-2018年丹麦行政登记册.
鉴定了31,301名3AVB患者,与对照进行1:5匹配.
采用多变量Cox和逻辑回归来分析CKD关联和心脏起器植入几率,按透析状态分层.

主要成果:

在调整为混因素后,观察到CKD和3AVB之间存在显著的关联 (HR:1.83;95%CI:1.73-1.93).
这种关联在透析患者 (HR:7.71;95% CI:5.84-10.18) 与非透析CKD患者 (HR:1.73;95% CI:1.64-1.83) 相比显著更强.
在透析患者中,心脏起器植入的几率较低 (OR:0.77;95% CI:0.60-0.98),但在非透析CKD和无CKD患者中相似.

结论:

慢性脏病是第三级心房阻塞 (3AVB) 的独立危险因素.
患有CKD的患者,尤其是透析患者,面临3AVB的风险大幅增加.
这些发现强调了心脏监测在CKD患者中的重要性.

关键词:

心血管阻塞心血管阻塞慢性脏疾病慢性脏疾病植入式心脏转换器-除器这是一个心脏起器.

更多相关视频

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents

Published on: July 3, 2013

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

相关概念视频

Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers

Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers

Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of...

Disturbances in Heart Rhythm

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...

Hormonal Regulation

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

Nephrons

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...