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在NMOSD和MOGAD的视觉生活质量:个人资料,动态和与衰老和视力相关的关联

Mihaela Nicolescu^1,2, Vivien Häußler³, Friedemann Paul^4,5,6

¹APHM, Hôpital de la Timone, CEMEREM, Marseille, France. m3nicolescu9@gmail.com.

Journal of neurology

|December 21, 2024

概括

与健康个体相比,神经omyelitis光学谱障碍 (NMOSD),MOGAD和多发性硬化症 (MS) 患者报告与视力相关的生活质量受损类似. 年龄和高对比度视力敏度显著影响这些生活质量得分.

科学领域:

神经科学是一个神经科学.
眼科医生眼科眼科
生活质量研究研究生命质量研究

背景情况:

神经脊髓炎光学谱系障碍 (NMOSD) 和髓寡基细胞糖蛋白抗体相关疾病 (MOGAD) 是影响中枢神经系统的炎症性脱髓化疾病.
视力障碍是这些疾病中常见且显著的症状,影响患者的日常生活.

研究的目的:

为了比较与视觉相关的生活质量 (VR-QoL) 和其与NMOSD,MOGAD,多发性硬化症 (MS) 和健康对照中的视觉障碍的关联.
在这些患者群体中确定影响VR-QoL的因素.

主要方法:

分析来自德国NEMOS注册的数据,包括国家眼科研究所视觉功能问卷 (NEI-VFQ),视力敏度 (HCVA,LCVA) 和神经学分数 (EDSS).
利用调整的线性混合效应模型来比较NEI-VFQ得分和疾病组和对照组之间的视力敏度相互作用.
平均随访时间为1.2年.

主要成果:

尽管MOGAD队列的年龄较小,但VR-QoL减少在NMOSD,MOGAD和MS患者组中与健康对照组相比相似.
一般健康,一般视力,驾驶和角色困难是最受影响的VR-QoL维度.
年龄是几个NEI-VFQ子尺度下降的主要预测因素,而高对比度视力敏度最好预测大多数子尺度.

结论:

患有NMOSD,MOGAD和MS的患者对视力和生活质量受损的感觉相似.
这些神经炎症状况导致相比于健康个体的生活质量较差,无论年龄差异如何.

关键词:

生活质量生活质量.在NEI-VFQQ中.这是NMOSD的NMOSD.神经炎症性疾病是一种神经炎症性疾病.视觉视觉视觉视觉视觉是一个视觉测试视觉测试视觉测试

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