西班牙抗菌素耐药性所造成的经济和人类负担:整体的成本宏观估计
1Faculty of Economics and Business, Department of Economics, Universidade da Coruña, Campus de Elviña, 15008, A Coruña, Spain. sabela.siabac@udc.es.
概括
在西班牙,抗菌素耐药性 (AMR) 导致超过6,000人过早死亡,每年造成3.386亿欧元的损失. 这项研究提供了宏观水平的估计,以告知这种日益增长的公共卫生威胁的制战略.
科学领域:
- 公共卫生 公共卫生
- 卫生经济学 卫生经济学
- 传染性疾病 传染性疾病
背景情况:
- 抗菌素耐药性 (AMR) 对医疗保健构成重大威胁,增加死亡率和成本.
- 目前对抗药物耐药性负担的估计是有限的,主要关注医院系统.
- 需要对西班牙AMR对人类和经济的影响进行宏观评估.
研究的目的:
- 在宏观层面上估计西班牙抗菌素耐药性 (AMR) 的经济和人类负担.
- 为医院以外的AMR影响提供全面的数据.
- 为制止AMR的政策和战略制定提供信息.
主要方法:
- 使用流行率,过早死亡和文献数据开发了一个经济模型.
- 使用住院护理 (医院外日),门诊护理 (补偿率) 和生产力损失 (人力资本方法) 的方法来评估成本.
- 来自EARS-NET,ESAC-NET和GBD的数据被用于30种细菌药物耐药性组合.
主要成果:
- 在西班牙,抗菌素耐药性 (AMR) 与77,870例感染,6,199例过早死亡和426,495个额外的住院日有关.
- 总经济成本达到3.386亿欧元 (占GDP的0.03%),其中直接成本为72%,间接成本为28%.
- 甲型抗菌耐药性导致失去了3,112年的工作寿命,其中格兰阴性细菌是主要的驱动因素.
结论:
- 这项研究提供了西班牙不同细菌和感染地点对抗药物耐药性成本的首次宏观评估.
- 调查结果强调了AMR带来的巨大经济和人力负担,强调了需要强有力的制战略的必要性.
- 这些估计对于了解抗药性问题的规模和有效的公共卫生规划至关重要.
相关概念视频
00:46Genomic DNA in Prokaryotes
43.4K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
Genomic Diversity in Bacteria
Although bacterial genomes are much...
43.4K
01:30Development of Antibiotic Resistance
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
00:57Antibiotic Selection
52.3K
Overview
52.3K
01:28Antimicrobial Effectiveness
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...