与药物相关问题的频率,类型和严重程度以及药剂师在Paxlovid®处方中的干预:描述性分析
Alina Stoiber1,2, Gwen Gray1, Gudrun Sailer2
1School of Pharmacy, Applied Sciences and Public Health, Robert Gordon University, Garthdee Road, Aberdeen, AB10 7QB, Scotland, UK.
International journal of clinical pharmacy
|December 21, 2024
概括
口服的COVID-19抗病毒药物Paxlovid经常引起药物相互作用,需要药剂师的干预. 药物相关问题的高率凸显了需要仔细的处方和监测,以确保患者的安全.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 传染性疾病 传染性疾病
背景情况:
- 帕克斯洛维德 (尼马特里尔维尔和里托纳维尔) 是唯一获得许可的COVID-19口服抗病毒药物.
- 帕克斯洛维德的成分里托纳维尔是一种强大的CYP450酶抑制剂,导致频繁的药物相互作用 (DDI).
研究的目的:
- 确定与Paxlovid处方相关的药物相关问题的发生率,性质和严重程度.
- 评估DDI和功能障碍对Paxlovid治疗的临床影响.
主要方法:
- 对维也纳一家公立医院处方Paxlovid的患者进行了回顾性定量分析.
- 临床药剂师使用标准化表格收集数据,并对数据样本进行独立验证.
- 利用已建立的互动检查工具进行DDI和严重程度分类;记录了针对功能障碍的剂量调整.
主要成果:
- 87.1%的患者需要干预以防止DRP;药剂师在发药时的干预在63.6%的病例中是必要的.
- 药物相互作用 (DDI) 是最常见的DRP (57.1%),影响了81.4%的患者,总共记录了313次DDI.
- 严重的DDI发生在17%的患者中;2.1%的患者因严重功能障碍而接受了帕克斯洛维德尽管禁忌.
结论:
- 药剂师的参与对于治疗Paxlovid的患者至关重要,因为Paxlovid具有很高的DDI潜力.
- 积极识别和管理DRP,包括DDI和功能障碍,对于安全使用Paxlovid至关重要.
- 确保患者安全需要药剂师在处方Paxlovid等相互作用药物时进行警监测和干预.
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