在最后一个普遍的共同祖先中,证据证明了科林生物合成
Luca D Modjewski1, Val Karavaeva2,3, Natalia Mrnjavac1
1Institute of Molecular Evolution, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Düsseldorf, Germany.
The FEBS journal
|December 21, 2024
概括
对于古老的二氧化碳固定至关重要的角质生物合成,起源于所有生命的最后一个普遍共同祖先. 这表明,腐蚀物在早期细胞的起源中起到了关键作用.
科学领域:
- 生物化学 生物化学
- 进化生物学 进化生物学
- 天体生物学 天体生物学
背景情况:
- 与维生素B12一样,类素是重要的代谢途径中的重要辅因子.
- 乙-CoA通路是一种原始的CO2固定方法,依赖于胺和铁硫蛋白 (CoFeS).
- 在古代考古中发现的甲基生物和细菌的乙基生物中发现了CoFeS,这表明了corrinoids的深层进化根源.
研究的目的:
- 为了研究科林生物合成的进化起源及其与古生物和细菌分化的关系.
- 为了确定corrin路径是否独立出现或在血统之间转移.
- 了解化物在生命早期和二氧化碳同化中的作用.
主要方法:
- 对26种参与科林环和较低联结体生物合成的酶进行基因分析.
- 关键酶的结构数据分析.
- 与已知的生化途径和进化模型进行比较.
主要成果:
- 胺合成途径可以追溯到所有生命的最后一个普遍共同祖先 (LUCA).
- 聚胺依赖的甲基合成途径可能在LUCA.之后在古生物学和细菌谱系中独立演变.
- 科林生物合成酶是从先前存在的古代途径中招募的.
结论:
- 科林生物合成是古老的,早于古生物和细菌的分化,可能起源于LUCA.
- 在早期的二氧化碳同化过程中,酶性科林生物合成可能已经取代了非生物性矿物催化剂.
- 科林合成与自由活细胞和地球上早期生命的起源有关.
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