相关实验视频

Updated: Jul 29, 2026

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Published on: June 18, 2020

代谢变化与hvpg在hcv肝硬化患者的daas治疗后hvpg的变化相关

Ana Virseda-Berdices^1,2, Rubén Martín-Escolano^1,2, Juan Berenguer^2,3,4

¹Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

Liver international : official journal of the International Association for the Study of the Liver

|December 21, 2024

概括

代谢物2,3-butanediol和taurocholic acid可能表明在治疗C型肝炎病毒 (HCV) 相关肝硬化后直接作用抗病毒药物 (DAA) 治疗后,门门高血压的变化,有助于监测肝脏并发症.

科学领域:

肝病学肝病学是一种肝病学.
代谢学代谢学代谢学
胃肠病学胃肠病学

背景情况:

直接作用抗病毒药物 (DAA) 治疗改善了晚期C型肝炎病毒 (HCV) 相关肝硬化病的结果.
降低肝静脉压梯度 (HVPG) 与减少肝脏并发症和增加存活率相关.
监测HVPG变化对于管理先进的HCV相关肝硬化至关重要.

研究的目的:

在DAA治疗期间和之后调查与HVPG变化相关的代谢变化.
在HCV肝硬化患者中确定门高血压演变的潜在生物标志物.

主要方法:

多中心纵向研究涉及31名患有晚期HCV相关肝硬化症的患者.
使用GC-MS和LC-MS进行非目标代谢分析.
通过Luminex技术分析炎症生物标志物,使用GLMM进行统计分析.

主要成果:

2,3-butanediol和taurocholic酸的水平增加与HVPG的上升有显著的关联.
这些代谢物变化与炎症生物标志物水平升高相关.
研究结果从基线观察到DAA治疗后48周.

结论:

2,3-butanediol和taurocholic acid显示出作为门高血压指标的潜力.
这些代谢物可能有助于跟踪HCV肝硬化病的疾病进展和治疗反应.

关键词:

在HCV病毒感染的过程中,艾滋病病毒艾滋病病毒艾滋病病毒这是HVPG的HVPG.肝硬化是肝硬化的一种疾病.代谢生物组的代谢生物组

更多相关视频

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

Published on: June 9, 2019

Inducing and Characterizing Vesicular Steatosis in Differentiated HepaRG Cells

Inducing and Characterizing Vesicular Steatosis in Differentiated HepaRG Cells

Published on: July 18, 2019

相关概念视频

Hepatitis

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...