关于衰老生物标志物的专家共识声明,用于干预研究
Giorgia Perri1, Chloe French2, César Agostinis-Sobrinho3,4
1Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
概括
专家们就长寿研究的14个关键衰老生物标志物达成共识. 这提供了一种标准化的方法来衡量旨在促进健康的干预措施的有效性.
科学领域:
- 老年学和长寿研究研究.
- 生物医学科学 生物医学科学
- 临床试验设计 临床试验设计
背景情况:
- 衰老的生物标志物对于评估促进长寿的干预措施至关重要.
- 关于人类干预研究中最适合的生物标志物存在缺乏共识.
- 需要标准化的结果测量来评估衰老干预措施的有效性.
研究的目的:
- 建立一个专家共识,适合人类干预研究的衰老生物标志物.
- 为长寿研究确定可靠和验证的生物标志物.
- 为未来的老化临床试验提供框架.
主要方法:
- 与国际专家小组成员一起进行了三轮的Delphi研究.
- 专家们通过在线平台对候选衰老生物标志物进行了建议和投票.
- 共识被定义为对生物标志物适用于干预研究的≥70%的同意.
主要成果:
- 在生理,炎症,功能和表观遗传领域的14个生物标志物达到了专家的共识.
- 包括生物标志物包括胰岛素样生长因子1,C反应蛋白,肌肉质量和表观遗传钟.
- 协商一致确定了对衰老干预研究的潜在结果措施.
结论:
- 一个专家的共识确定了14个关键的衰老生物标志物用于干预研究.
- 这些生物标志物代表着在长寿研究中标准化结果衡量的重要一步.
- 建议进行进一步的研究,以确定这些生物标志物的最佳组合,以评估干预效用.
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