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Updated: Jun 4, 2025

A New Straightforward Method for Lipophilicity logP Measurement using 19F NMR Spectroscopy
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A New Straightforward Method for Lipophilicity logP Measurement using 19F NMR Spectroscopy

Published on: January 30, 2019

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通过使用替代有机溶剂修饰剂的逆相液态染色学预测中性化合物的八醇-水分离常数

Sanka N Atapattu1, Colin F Poole2

  • 1CanAm Bioresearch Inc. Winnipeg, MB R3T 0P4, Canada.

Journal of chromatography. A
|December 21, 2024
PubMed
概括

逆相液态染色学 (RPLC) 提供了一种更快,更自动的方法来确定药物发现中至关重要的八醇-水分离常数. 具有特定RPLC列的乙和四基修饰剂提供了准确的预测模型.

关键词:
其他溶剂替代溶剂.八度醇-水分区分逆相液态染色学 逆相液态染色学解决参数模型的解决参数模型

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