在伦敦,胆管形和胆管形缺陷的比较人口统计
Francesca Maestri1, Kat Ford1, Erica Makin1
1Dept. of Paediatric Surgery, Kings College Hospital, London, UK.
Journal of pediatric surgery
|December 21, 2024
概括
这项研究发现,伦敦市内有全球胆道动 (BA) 发病率最高的地区. 胆道形 (CM) 发生率也高于预期,在两种情况中观察到的人口变化.
科学领域:
- 儿科胃肠病学和肝病学
- 遗传胆道异常 遗传胆道异常
- 婴儿和童年疾病的流行病学.
背景情况:
- 胆道形 (CM) 和胆道形 (BA) 是儿科患者的关键胆道病理.
- 了解共同的人口特征可以为病因学研究和公共卫生战略提供信息.
研究的目的:
- 在特定的地理和时间区域内调查胆道形 (CM) 和胆道形 (BA) 之间的共同人口特征.
- 确定伦敦CM和BA的发病率,并分析人口统计学变化.
主要方法:
- 在1999-2022年期间在伦敦大都会出生的患者的未来识别.
- 使用多重贫困指数 (IMD) 排名指数和活产数据进行发病率分析.
- 使用Poisson分布和Chi2测试进行统计评估 (P ≤0.05显著).
主要成果:
- 发病率:BA 7.45/100,000,CM 2.9/100,000,没有时间变化.
- 在伦敦内区 (9.42/100,000) 的BA发病率明显较高.
- CM显示女性占主导地位 (77%);这两个群体的非白人种族代表性更高. 伦敦内城区在CM和BA的IMDR中显示出明显的差异.
结论:
- 在欧洲和北美,伦敦内区的胆道动 (BA) 报告发生率最高.
- 观察到的胆固醇形 (CM) 发病率超过了先前的预期,代表了第一个观察发病率数据.
- 人口变化,包括种族和社会经济地位 (IMDR),与伦敦的BA和CM发病率相关.
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