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嗅觉球泡微细胞激活在臭氧暴露的小鼠中通过嗅觉和认知功能障碍来调解神经元灭

Ranhong Xu¹, Haiyu Chen¹, Yougang Wang¹

¹Hubei Clinical Research Center for Alzheimer's Disease, Brain Science and Advanced Technology Institute, School of Medicine, Wuhan University of Science and Technology, Wuhan, China.

Journal of hazardous materials

|December 21, 2024

概括

臭氧暴露会损害嗅觉和认知功能,导致神经炎症和嗅觉球中的突触损伤. 米诺环素治疗可以逆转这些效应,突出了潜在的治疗标.

科学领域:

神经科学是一个神经科学.
环境健康环境健康
毒理学毒理学毒理学

背景情况:

热带空气污染物,特别是臭氧,正在增加.
对臭氧对嗅觉和认知功能影响的研究是有限的.
嗅球 (OB) 的组织病理变化已知,但功能后果需要进一步研究.

研究的目的:

研究慢性臭氧暴露对嗅觉和认知功能的影响.
为了阐明臭氧诱导的神经炎症和神经突触损伤的潜在机制.
评估米诺环林在减轻臭氧有害影响方面的治疗潜力.

主要方法:

暴露C57BL/6小鼠1.0ppm臭氧13周.
嗅觉和认知功能的评估.
对OB组织进行免疫组织化学分析,以检查微质激活,突触标记物 (PSD95,Synaptophysin),C1q,GSDMD-N和神经元标记物 (Iba1,NEUN).
用米诺环林来评估其保护作用.

主要成果:

臭氧暴露导致了显著的嗅觉和认知障碍.
在OB中观察到活化的微质细胞和神经炎症.
降低突触蛋白 (PSD95,Synaptophysin) 的下调,减少树突长度和脊柱密度.
微质细胞通过C1q介导的突触细胞形成的证据.
暴露在臭氧中引发了神经元灭.
米诺环素的使用改善了臭氧引起的缺陷.

结论:

长时间暴露于臭氧会导致OB微质激活,导致突触损伤和神经元灭.
这些病理变化导致嗅觉和认知功能障碍.
米诺环素在缓解臭氧诱导的神经炎症和功能障碍方面表现有前途.

关键词:

认知障碍认知障碍是一种认知障碍.微质细胞中的微质细胞嗅觉功能障碍嗅觉功能障碍臭氧臭氧是什么?臭氧臭氧是什么热灭菌的发生.

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