模块化自我乳化药物输送平台,以增强三阴性乳腺癌的细胞吸收活性
Nandini Gandhi1, Shail Modi1, Shailvi Soni1
1Massachusetts College of Pharmacy and Health Sciences (MCPHS University) Department of Pharmaceutical Sciences, School of Pharmacy, 19 Foster St., Worcester, MA 01608, USA.
概括
这项研究引入了一种新型的自我乳化药物输送系统 (SEDD),以改善三阴性乳腺癌 (TNBC) 的西斯和siRNA输送. 该SEDD配方增强细胞吸收,为TNBC治疗提供了一个有前途的方法.
科学领域:
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
- 在瘤学瘤学.
背景情况:
- 三阴性乳腺癌 (TNBC) 对诸如西斯普拉丁之类的疗法表现出耐药性,需要更高的剂量与相关的毒性.
- 目前治疗的局限性包括获得的瘤耐药性,脏毒性和患者对西斯的可变反应.
- 为了克服这些挑战,TNBC正在探索双重药物输送策略.
研究的目的:
- 开发和优化一种自乳化药物输送系统 (SEDD),用于在TNBC中联合输送西斯和siRNA.
- 证明SEDDs在增强小分子和大分子的细胞内吸收方面的潜力.
- 在TNBC治疗中使用SEDD进行双重药物递送的原则证明.
主要方法:
- 使用伪三元相图准备和优化四个SEDD配方.
- 关于尺寸,多分散性 (PDI) 和表面电荷的SEDD配方的表征.
- 在体外测试和通过药物装载SEDDs的三重染色对细胞吸收的调查.
主要成果:
- 优化的SEDD配方成功地促进了水在油中的水 (w/o/w) 乳液的形成.
- 在SEDD中,cisplatin和siRNA的细胞内化得到了增强.
- 观察到TNBC细胞对SEDD的选择性吸收,表明有针对性的传递潜力.
结论:
- 该SEDDs平台是有效的共同交付西斯 (小分子) 和siRNA (大分子).
- 这种方法有望克服西斯胺耐药性,并改善三阴性乳腺癌的治疗结果.
- 该研究为TNBC治疗中的双重药物输送系统提供了基本的原则证明.
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