在喘管理中改变范式
Charles E Grogan1, Marlee Wadsworth1, Gailen D Marshall1
1Division of Clinical Immunology, The University of Mississippi Medical Center, Jackson, MS, USA.
The American journal of the medical sciences
|December 21, 2024
概括
先进的喘疗法针对特定的炎症途径,提供个性化治疗. 然而,高成本和可变的患者反应需要探索具有成本效益的替代方案,并进一步研究最佳治疗选择.
科学领域:
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 喘是一种慢性呼吸道炎症疾病,严重程度可变.
- 目前先进的治疗方法针对特定的炎症途径,如IgE,IL-5,IL-4受体和TSLP.
- 这些向疗法在中度至重度的持续性喘中表现出有效性.
研究的目的:
- 审查当前先进的喘治疗方法.
- 为了解决这些治疗的重大财务负担.
- 探索替代策略和个性化治疗选择的需要.
主要方法:
- 关于喘病理生理学和治疗的当前文献的综述.
- 对已批准和正在研究的生物疗法进行分析.
- 讨论成本效益和患者反应的变化.
主要成果:
- 有几种向治疗 (抗IgE,抗IL-5,抗IL-4Rα,抗TSLP) 可用于中度至重度喘.
- 生物疗法的高成本对患者和医疗保健系统构成负担.
- 患者对当前疗法反应的变化是一个重大的临床挑战.
结论:
- 新型疗法已经推进了喘管理,但成本和反应变化仍然令人担忧.
- 探索吸入性皮质类固醇和长效支气管扩展剂的新用途可能会提供具有成本效益的替代品.
- 进一步的研究至关重要,以确定生物标志物,以预测患者对特定先进喘疗法的反应.
相关概念视频
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
236
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
236
Asthma: Pathogenesis and Management
348
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
348
Asthma-IV: Nursing Management
3.0K
The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
First, in...
3.0K
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
COPD: Management Using Bronchodilators and Corticosteroids
177
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
177


