手术后前30天的阿片类药物消费与新的持续阿片类药物使用独立相关
Brittany A Ervin-Sikhondze1, Vidhya Gunaseelan2, Kao-Ping Chua3,4,5
1Department of Anesthesiology, Michigan Medicine, Ann Arbor, Michigan, USA.
Regional anesthesia and pain medicine
|December 21, 2024
概括
手术后在手术后30天内服用阿片类药物与新的持续阿片类药物使用有关. 管理早期阿片类药物摄入对于预防手术后的长期阿片类药物依赖至关重要.
科学领域:
- 疼痛管理 疼痛管理
- 成 药物 药物 药物 药物
- 外科手术的结果
背景情况:
- 以前的研究将较大的阿片类药物处方与手术后的新持续阿片类药物使用 (NPOU) 联系起来.
- 没有明确NPOU和实际术后阿片类药物消费之间的直接关联.
研究的目的:
- 调查患者在手术后的前30天报告的阿片类药物消费与新持续阿片类药物使用 (NPOU) 的发展之间的关系.
主要方法:
- 在密歇根州70家医院 (2018-2021) 接受手术的36,271名先前未使用过阿片类药物的患者的回顾性分析.
- 利用了密歇根外科质量协作和该州处方药监测计划的链接数据.
- 多变量后勤回归评估了30天阿片类药物消费和NPOU之间的关联 (定义为阿片类药物填充在出院后的31-120和121-210天).
主要成果:
- 1.3% (482) 的患者出现了NPOU.
- 与没有NPOU (平均4.1片) 患者相比,NPOU患者在前30天消费的阿片类药丸显著增加 (平均7.3片).
- 术后消耗的每一种额外的阿片类药丸都会使NPOU的概率增加0.05个百分点.
结论:
- 在最初的30天内术后的阿片类药物消费是新持续性阿片类药物使用 (NPOU) 的独立预测指标.
- 这一发现凸显了外科手术期间阿片类药物处方策略在缓解长期阿片类药物使用和依赖方面发挥的关键作用.
- 优化早期术后阿片类药物管理对于改善患者长期治疗结果至关重要.
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