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系统性免疫炎症指数与成年喘患者的长期全因和因特定死亡率之间的关系:基于人口的研究
Zhuanbo Luo1, Shiyu Chen1, Ning Zhu1
1Department of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Ningbo, The First Affiliated Hospital of Ningbo University, 59 Liuting Road, Ningbo, Zhejiang, 315010, China.
系统性免疫炎症指数 (SII) 与喘患者的死亡率增加有关,特别是来自心血管和呼吸系统疾病. 这种关联遵循J形曲线,表明SII水平非常低和高的风险.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 喘的特点是持续的呼吸道炎症.
- 关于全身免疫炎症指数 (SII) 和喘死亡率的研究有限.
- 像SII这样的新型炎症标志物需要在慢性呼吸道疾病中进行调查.
研究的目的:
- 研究喘患者SII与全因和因特定死亡率之间的关联.
- 使用先进的统计方法探索SII和死亡率之间的潜在非线性关系.
- 通过子组和灵敏度分析验证发现.
主要方法:
- 分析国家健康和营养检查调查 (NHANES) 数据 (1999-2018).
- 权衡的卡普兰-梅尔和多变量调整的考克斯比例危险模型.
- 对非线性关联进行受限立方线 (RCS) 分析.
主要成果:
- 在5384名喘患者中,发现SII升高与因任何原因,心血管和呼吸系统疾病增加的死亡率之间存在联系.
- 在SII和这些死亡结果之间观察到J形非线性关系.
- 在各种子组中,SII是所有原因死亡率的重要预测因素.
结论:
- 升高的SII水平与喘患者全因,心血管和呼吸道死亡的风险更高有关.
- 喘中SII和死亡率之间的关系呈现出非线性,J形的模式.
- SII可以作为喘死亡风险的预后生物标志物.
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