试验前知识动员的协作工作组方法:对结构化过程的定性评估,以代地完善复杂的干预 (DAFNEplus).
J P Breckenridge1, R Gossage-Worrall2, P Chadwick3
1School of Health Sciences, University of Dundee, Dundee, UK.
Pilot and feasibility studies
|December 21, 2024
概括
这项研究引入了一个合作工作组 (CWG),在试验之前改进复杂的干预措施. 该CWG被证明是可以接受和可行的,突出了成功动员研究知识的关键要素.
科学领域:
- 医疗保健服务研究 医疗服务研究
- 干预 发展 干预
- 知识动员知识动员
背景情况:
- 缺乏在审判前阶段动员知识的实际指导.
- 关于复杂干预的现有指导往往是理论上的,而不是实际的.
- 在随机对照试验之前,需要结构化的方法来改进干预措施.
研究的目的:
- 评估协作工作组 (CWG) 的过程,以代地改进复杂干预的试验前过程.
- 在干预开发中分享知识动员的实用经验教训.
- 为未来的研究团队提供指导.
主要方法:
- 在DAFNEplus研究计划中对CWG过程进行了嵌入式定性评估.
- CWG包括每月的电话会议和面对面的会议,以分享知识.
- 通过重点小组,个人访谈和文档分析收集的数据.
主要成果:
- 参与者发现CWG是可以接受的,可行的,并且对试验前干预精细化有用.
- 关键的成功因素包括知识道,信任谈判,平衡实用性,认识论妥协和管理权力动态.
- 为建立信任和知识共享提供足够的时间和资源至关重要.
结论:
- 该CWG提供了一种实用方法,以使协作干预的操作化成为可行的.
- 为研究团队提供有形的教训和建议.
- 增加了对干预开发和知识动员领域的实际指导.
相关概念视频
Clinical Trials
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Preclinical Development: Overview
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Study Designs in Epidemiology
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Strategies for Assessing and Addressing Confounding
Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
Community Based Intervention
Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...


