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Updated: Jun 4, 2025

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饮食疗法通过重塑血胆固醇纳米基因减轻突变APC和KRas的影响

Eunjoo Kim1, Alfredo Erazo-Oliveras2, Mónica Muñoz-Vega2

  • 1Program in Integrative Nutrition & Complex Diseases, Texas A&M University, College Station, Texas; Department of Molecular and Cellular Medicine, Texas A&M University, College Station, Texas.

Biophysical journal
|December 22, 2024
PubMed
概括

突变的APC-KRas破坏结肠细胞胆固醇平衡,增加膜秩序和促进癌症. 某些食脂质和黄素可以逆转这些影响,为结直肠癌提供潜在的治疗方法.

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Receptor Downregulation in MVBs01:15

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Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
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