后背条体中细胞类型特定的电路对听觉决策的因果贡献
Lele Cui1, Shunhang Tang1, Jingwei Pan2
1Institute of Neuroscience, Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China.
脊椎条状体 (DS) 中的直接和间接通路条状投影神经元 (dSPN和iSPN) 具有相反的作用. 研究了他们对决策的具体贡献,特别是在困难的审判中.
科学领域:
- 神经科学是一个神经科学.
- 决策研究 决策研究
- 发动机控制器 发动机控制器
背景情况:
- 背上条纹体 (DS) 对于行动控制至关重要.
- 直接通路 (dSPN) 和间接通路 (iSPN) 条状投影神经元具有相反的作用.
研究的目的:
- 调查dSPNs和iSPNs在后部DS (pDS) 中在听觉引导决策过程中的不同角色.
- 了解这些神经元路径是如何专门为决策过程做出贡献的.
主要方法:
- 使用因果询问技术来操纵dSPN和iSPN在pDS中的活动.
- 在听觉引导的决策任务中,神经元活动被调节.
- 使用了非激活和临时特定激活方法.
主要成果:
- 单方面激活dSPNs或iSPNs诱导强烈的,对立驱动在选择行为,无论任务的难度.
- 失活dSPN或iSPN导致了显著的选择偏差,特别是在更困难的试验中.
- 在决策期内暂时特定的iSPN激活,但在决策期之外没有,偏见的选择.
- 两种途径的同时消抑制 (通过帕瓦胺内部神经元的不激活) 导致主要在困难的试验中产生逆侧偏差.
结论:
- dSPNs和iSPNs对选择行为做出了独特和决策特定的贡献.
- 对于有效的决策过程来说,dSPN和iSPN的协调活动至关重要.
- 这些发现阐明了条状通路在将感官信息转化为行动中的特定作用.
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