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Updated: Jun 4, 2025

Detection of Copy Number Alterations Using Single Cell Sequencing
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在单细胞分辨率下对体变异进行全基因组分析的协议,使用初级模板定向DNA放大

Lucca L M Derks1, Anaïs J C N van Leeuwen1, Alexander S Steemers1

  • 1Princess Máxima Center for Pediatric Oncology, Utrecht 3584 CS, the Netherlands; Oncode Institute, Utrecht 3521 AL, the Netherlands.

STAR protocols
|December 22, 2024
PubMed
概括

本研究提出了一种工作流程,用于分析单细胞体突变,使用初级模板定向放大 (PTA) 和机器学习工具 (PTATO) 来准确地区分真实突变和工件.

关键词:
生物信息学是一种生物信息学.癌症 癌症 癌症 癌症 癌症分子生物学分子生物学序列分析分析的序列分析.测序的测序是指测序的测序.

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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
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