在精神分裂症,双相情感障碍和注意力缺陷/多动性障碍中,休息状态功能连接度的改变合关系
Lu Ma1, Shanshan Jiang1, Wei Tang2
1Department of Radiology, Tsinghua University Hospital, Beijing 100084, China.
Psychiatry research. Neuroimaging
|December 22, 2024
概括
这项研究揭示了精神分裂症,双相情感障碍和多动症的空间和时间连接模式的改变. 这些明显的脑连接变化为这些精神疾病的神经病理学提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 休息状态功能连接 (rsFC) 对于理解精神分裂症 (SZ),双相情感障碍 (BD) 和注意力缺陷/多动症障碍 (ADHD) 至关重要.
- 在这些疾病中,rsFC测量的变化的空间和时间合仍未得到充分研究.
研究的目的:
- 调查与健康对照 (HC) 相比,SZ,BD和ADHD患者的rsFC测量空间和时间合的变化.
- 探索改变的rsFC合和SZ和BD的临床症状之间的关系.
主要方法:
- 利用来自HC,SZ,BD和ADHD个体的跨诊断样本的静止状态fMRI数据.
- 采用肯德尔的W来计算rsFC测量的体积和声量一致性.
- 进行了 rsFC 和临床症状之间的组比较和相关性分析.
主要成果:
- 与HC相比,SZ和BD组显示体积智能空间一致性下降.
- SZ个体在右侧尾皮层表现出较低的声音智的时一致性.
- 患有BD的个体在基底前脑和状回形中表现出较低的声音智的时一致性.
- 在左基底前脑的声音智能一致性与SZ和BD的负面症状正相关.
结论:
- 在rsFC测量中,在SZ,BD和ADHD中发现了空间和时间脱的明显模式.
- 这些发现为这些精神疾病背后的神经病理机制提供了新的见解.
- 改变的大脑连接可能成为区分和理解这些疾病的潜在生物标志物.
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