维生素D水平与移植与宿主疾病之间是否存在关系?
Tugce Nur Yigenoglu1, Bahar Uncu Ulu1, Sinem Namdaroglu2
1University of Health Sciences, Ankara Oncology Training and Research Hospital, Department of Hematology & Apheresis Unit, Ankara, Turkey.
概括
维生素D缺乏症常见于接受异性造血干细胞移植 (allo-HSCT) 的患者. 在这些患者中,更高的移植前维生素D水平与更高的生存率有关.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 移植医学 移植医学
背景情况:
- 维生素D缺乏症在接受全源造血干细胞移植 (allo-HSCT) 的成年患者中普遍存在.
- 维生素D在免疫系统调节中起着至关重要的作用,可能会影响移植结果.
研究的目的:
- 调查移植前维生素D水平对接受alo-HSCT的患者结果的影响.
- 评估维生素D状态与抗瘤活性,复发,移植与宿主疾病 (GVHD) 和感染率之间的关系.
主要方法:
- 在土耳其七个中心对211名接受allo-HSCT的患者进行了回顾性分析.
- 对移植前维生素D水平的评估与整体存活率 (OS),复发率,GVHD发生率和移植时间有关.
主要成果:
- 移植前的维生素D水平与中性粒细胞移植日,复发率或GVHD发生率没有明显的相关性.
- 较高的维生素D水平 (>12 ng/mL) 与改善的整体存活率 (p=0.029) 显著相关.
- 在14个月的中位数随访后,整体存活率为84.8%.
结论:
- 移植前的维生素D水平与alo-HSCT接受者的GVHD,复发或移植时间无关.
- 移植前维生素D水平升高 (>12 ng/mL) 与接受alo-HSCT的患者的存活率提高有关.
- 需要进一步进行大规模研究,以阐明维生素D在Allo-HSCT结果中的确切作用.
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