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皮克林乳液与瘤血管破坏和微环境调制用于跨动脉栓塞治疗

Lei Zhang¹, Duo Wang¹, Lin-Zhu Zhang¹

¹Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University), Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, China; National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University), Nanjing, 210009, China; Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, Southeast University, Nanjing, 210009, China; State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, 210009, China.

|December 22, 2024

概括

新的Lipiodol Pickering乳液由酸纳米颗粒稳定,通过破坏瘤血液供应和逆转免疫抑制瘤微环境,改善肝细胞癌治疗.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

利皮多尔化疗乳液是肝细胞癌 (HCC) 跨动脉化学栓塞 (TACE) 的标准.
传统的乳液稳定性不佳,导致药物迅速扩散,不完全栓塞,全身毒性和TACE疗效降低.
改进的配方对于提高HCC治疗的安全性和有效性至关重要.

研究的目的:

使用酸 (CaP) 纳米粒子开发一种稳定,对pH值有反应的Lipiodol Pickering乳液 (LPE).
为了将血管干扰剂combretastatin A4-phosphate (CA4P) 封装到CaP-LPE系统 (CCaP-LPE) 中.
评估CCaP-LPE在破坏瘤血管,调节瘤微环境 (TME) 和治疗HCC.治疗中的有效性.

主要方法:

制备了 CaP纳米颗粒稳定的 Lipiodol Pickering 乳液 (CaP-LPE).
将康培拉酸甲4-酸盐 (CA4P) 封装到CaP-LPE中以形成CCaP-LPE.
对CCaP-LPE稳定性和pH响应药物释放的评估.
评估CCaP-LPE对瘤血管干扰,TME调节 (CD8+T细胞透,免疫抑制细胞减少) 和HCC瘤生长在 орто托普性大鼠模型中的影响.

主要成果:

与传统的Lipiodol乳液相比,CCaP-LPE表现出更好的稳定性.
该配方证明了封装的CA4P的pH响应释放.
CCaP-LPE有效地破坏了瘤血管系统,并通过中和酸性来逆转免疫抑制性TME.
这导致CD8+ T细胞透率增加,免疫抑制细胞减少.
通过诱导强烈的抗瘤免疫反应,CCaP-LPE显著抑制了大鼠的正型HCC瘤生长.

结论:

新型CaP-LPE为HCC治疗提供了更好的稳定性和pH响应的药物释放.
CCaP-LPE有效地准瘤血管系统,并调节免疫抑制TME.
这种方法对推进HCC的跨动脉化学栓塞治疗具有重大前景.

关键词:

免疫治疗是一种免疫疗法.皮克林乳液是皮克林乳液中的一种.通过动脉的化学栓塞 (TACE)瘤微环境是一个微环境.血管破坏剂 (VDAs) 是一种血管破坏剂.

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