意大利17例Mycobacterium marinum感染病例:一个多中心的回顾性研究
Bianca Granozzi1, Martina Casarini2, Niccolò Riccardi3
1Infectious Diseases Unit, Department for Integrated Infectious Risk Management, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Diagnostic microbiology and infectious disease
|December 22, 2024
概括
Mycobacterium marinum感染往往被误诊,导致治疗延迟. 长期的抗生素治疗,有时还需要手术,可以解决这些罕见的感染.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 菌根菌感染很少见,经常被误诊,并可能导致严重的后果,特别是在免疫受损的个体.
- 及时诊断和适当的治疗,包括长期的抗生素和手术,对于管理M. marinum感染至关重要.
研究的目的:
- 描述M. marinum感染的流行病学,临床和细菌学特征.
- 在一个多中心的回顾性研究中评估M. marinum感染的治疗结果.
主要方法:
- 一项多中心的回顾性研究使用了来自意大利五家医院的数据进行.
- 招募了17名被诊断患有M. marinum感染的受试者.
主要成果:
- 从症状出现到诊断的中位时间为124天.
- 在17例病例中,有13例细菌学上得到证实.
- 大多数患者接受至少两种抗生素中位数为6个月,达到临床解决.
结论:
- 延迟诊断M. marinum感染是很常见的.
- 长期的抗生素治疗,通常与外科手术相结合,导致临床解决.
- 需要进一步的前性研究和随机对照试验来优化治疗方案和持续时间.
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