来自Yupingfeng颗粒的多糖因保护肠道屏障而改善了循环胺诱导的免疫损伤
Leyi Huang1, Mo Liu2, Longhai Shen2
1Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201201, China; National Key Laboratory of Lead Druggability Research, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
International immunopharmacology
|December 22, 2024
概括
玉平峰颗粒 (YPFP) 中的多糖类通过恢复肠道屏障完整性和调节免疫细胞平衡,保护免受环胺诱导的免疫损伤. 这项研究揭示了YPFPFP.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 环胺 (CP) 诱导免疫损伤,通常与肠道屏障破坏有关.
- 玉平峰颗粒 (YPFP) 具有免疫调节特性,归因于它们的多糖成分.
- 了解YPFP的防护机制,以防止CP引起的损害至关重要.
研究的目的:
- 调查YPFP对循环胺诱导的免疫损伤的改善作用.
- 为了阐明潜在的机制,专注于肠道屏障.
- 探索YPFP对肠道微生物群,代谢物和免疫细胞群的影响.
主要方法:
- YPFP的分离和特征.
- 在CP诱导的免疫损伤模型中对YPFP的药理学评估.
- 评估肠道屏障的完整性 (紧密的接口,MUC-2).
- 用于肠道微生物群分析的16S rRNA测序.
- 代谢学分析内源代谢产物和途径.
- 流细胞测量用于评估免疫细胞群 (Th17,Treg).
主要成果:
- YPFP减轻了免疫器官的病变,并使白细胞数量正常化.
- 肠道屏障完整性得到修复,紧密结节和MUC-2表达得到改善.
- 肠道微生物群的组成发生了转变,有利于有益的细菌,如Muribaculaceae和Bacteroides.
- 代谢分析显示,脂质,胆酸 (例如,3-oxo-LCA) 和短链脂肪酸 (SCFA) 概况发生变化.
- YPFP 抑制了 PI3K-AKT 和 MAPK-JUN 信号通路.
- 通过重塑Th17/Treg细胞平衡,恢复了免疫平衡.
结论:
- YPFP有效地减轻了循环胺诱导的免疫损伤.
- 保护作用通过涉及肠道平衡的多种机制进行介导.
- YPFP修复肠道屏障,调节肠道微生物群和代谢物,并重新平衡免疫细胞.
- YPFP显示出作为一种免疫调节剂的潜力,可以缓解药物诱导的免疫损伤.
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