作为认知障碍和大脑损伤之间的机制性联系的Kynurenine通路失调:对多发性硬化症的影响
Marie Kupjetz1, Tiffany Y Wences Chirino1, Niklas Joisten2
1Research Group 'Sports Medicine', Institute for Sport and Sport Science, TU Dortmund University, Otto-Hahn-Str. 3, Dortmund 44227, Germany.
Brain research
|December 22, 2024
概括
因炎症而改变的kynurenine通路可能会在多发性硬化症 (MS) 中将脑损伤和认知障碍联系起来. 需要进一步的研究来证实它在多发性硬化症病理生理学中的作用.
科学领域:
- 神经免疫学 神经免疫学
- 代谢途径 代谢途径
- 神经科学是一个神经科学.
背景情况:
- 认知障碍是多发性硬化症 (MS) 的关键症状,由炎症引起的脑损伤和网络功能障碍驱动.
- 炎症扰乱了金氨酸通路,改变了神经毒性托芬催化剂 (金氨酸) 的水平.
- 这些kynurenines与MS病理生理学共享机制,表明与大脑损伤和认知衰退的联系.
研究的目的:
- 审查 kynurenine 途径失调和 MS 中 kynurenines 的神经免疫作用.
- 总结证据,将系统性 kynurenines 与大脑成像标记物和认知功能联系起来.
- 提出未来的研究方向,以了解金林途径在MS相关认知障碍中的作用.
主要方法:
- 关于与炎症相关的金氨酸通路失调的文献综述.
- 关于金氨酸与神经成像和认知相关的证据综合.
- 透视性文章概述了一个研究议程.
主要成果:
- 基努瑞宁通路失调与MS相关的神经炎症有关.
- 有证据表明,金氨酸水平,大脑结构变化和认知缺陷之间存在联系.
- kynurenine 途径是系统性炎症和MS 认知障碍之间的潜在机械联系.
结论:
- kynurenine 途径是理解和潜在治疗多发性硬化症认知障碍的有希望的目标.
- 进一步的研究对于阐明精确的机制至关重要.
- 研究kynurenines可能会导致MS的新疗法策略.
相关概念视频
01:37Neural Regulation
39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
95
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
95
01:29Drugs Affecting Neurotransmitter Synthesis
1.3K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.3K
01:28Disorders of the Nervous Tissue
1.1K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises...
1.1K
00:49The Blood-brain Barrier
46.7K
Overview
46.7K
01:23Role of Neurotransmitters in Memory
428
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
428