用密度计,微型计算机断层扫描和组织形态计来描述饮食脂肪和糖对骨健康的影响
J Khan1, H Sadie-Van Gijsen2, L M Kotzé-Hörstmann3
1Division of Clinical Anatomy, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University Tygerberg Campus, PO Box 241, Cape Town 8000, South Africa.
不同的肥胖性饮食对大鼠的骨健康有着截然不同的影响. 中等脂肪/高糖饮食有利于骨,而高脂肪/高果糖饮食会损害骨,这可能是由于勒素等循环因子的改变.
科学领域:
- 内分泌学和骨生物学 骨生物学
- 营养科学 营养科学
- 代谢研究研究 代谢研究
背景情况:
- 肥胖饮食可能会对系统代谢和骨健康产生负面影响.
- 关于高脂肪 (HF) 和高糖 (HS) 饮食对骨微观结构的影响的现有研究产生了矛盾的发现.
- 了解各种肥胖性饮食对骨的差异影响对于代谢和骨健康研究至关重要.
研究的目的:
- 为了比较中等脂肪/高糖 (MF/HS) 饮食与高脂肪/高果糖 (HF/Fr) 饮食对大鼠股骨的影响.
- 研究这些饮食对骨矿物质含量和密度 (BMC,BMD),微观结构和骨细胞群的影响.
- 为了探索循环骨向因素 (莱普丁,阿迪波内克丁,胰岛素) 和骨参数之间的相关性.
主要方法:
- 断奶的雄性Wistar大鼠被食控制,MF/HS或HF/Fr饮食17周.
- 骨密度计用于测量BMC和BMD.
- 微型计算机断层扫描 (μCT) 评估了皮层和无骨骨的微型架构.
- 组织形状测量量了骨质母细胞 (N.Ob),骨质母细胞 (N.Oc),脂肪细胞 (N.Ad) 和淋巴细胞 (N.Ch) 的数量.
主要成果:
- 一般来说,MF/HS饮食对骨参数有好处.
- 这种HF/Fr饮食对BMC,BMD,骨微观结构和骨细胞种群产生了不利影响.
- 血清勒丁与骨质母细胞数量和皮层和结骨的骨形成参数具有正相关性.
结论:
- 肥胖性饮食的特定成分显著影响骨健康结果.
- 饮食引起的循环因子的变化,特别是素,在调节骨代谢方面发挥作用.
- 这些发现有助于解释文献中关于不同肥胖原性饮食模式对骨的影响的相互矛盾的结果.
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