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双F对F1代雄性小鼠生殖功能的影响及其潜在机制

Bo Li¹, Siming Huo¹, Jiayu Du¹

¹Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.

Environmental pollution (Barking, Essex : 1987)

|December 22, 2024

概括

孕期暴露于双F (BPF) 会导致丸损伤,并降低男性后代的精子质量. 通过抑制关键途径,BPF扰乱了视网醇代谢和合成,导致生殖功能障碍.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
生殖生物学生殖生物学

背景情况:

双F (BPF) 是一种穿越胎盘屏障的内分泌干扰物.
关于BPF对男性后代生殖功能影响的研究有限.

研究的目的:

调查妊娠期BPF暴露对男性后代生殖健康的影响.
阐明BPF诱导的生殖毒性的潜在机制.

主要方法:

怀孕的小鼠在妊娠和哺乳期间暴露于BPF (40,400,4000μg/kg).
评估了F1男性后代的丸损伤,水平和精子质量.
利用转录学来探索分子机制.

主要成果:

在F1男性中,BPF暴露导致丸损伤,丸激素降低和精子质量受损.
转录学揭示了BPF破坏了视网醇代谢和精子生成.
通过改变脱水氨 (DHEA) 的代谢,BPF干扰了丸激素的合成.
BPF抑制了cAMP信号通路,阻碍了线粒体胆固醇运输和的产生.

结论:

孕期BPF暴露会导致男性后代显著的生殖功能障碍.
由BPF引起的生殖毒性涉及对丸功能至关重要的代谢和信号通路的破坏.

关键词:

双 F F 是一种双.精子发生障碍精子发生障碍丸受伤是因为丸受伤.的合成障碍的合成障碍

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