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在南非的Clostridioides difficile感染和测试率:一个多中心研究,2017-2020年

Trusha Nana¹, Praksha Ramjathan², Khine Swe-Swe Han²

¹Department of Clinical Microbiology, Faculty of Health Sciences, University of Witwatersrand, 7 York Road, Parktown, Gauteng, 2193, South Africa; National Health Laboratory Service, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, Gauteng, South Africa.

|December 22, 2024

概括

在2017年至2020年期间,南非三个医院的Clostridioides difficile感染 (CDI) 率显著变化. 测试实践也存在差异,在2020年SARS-CoV-2爆发期间,CDI显著增加.

科学领域:

传染性疾病传染性疾病
流行病学流行病学
公共卫生公共卫生

背景情况:

困难菌感染 (CDI) 是一个重要的医疗相关感染.
对CDI率和测试实践的监督对于有效管理至关重要.
了解CDI流行病学的变化对于有针对性的干预措施至关重要.

研究的目的:

为了确定Clostridioides difficile感染 (CDI) 率和检测实践.
为了比较南非 (SA) 三家三级/四级医院的CDI流行病学.
分析2017年至2020年的趋势,包括SARS-CoV-2疫情的影响.

主要方法:

复杂菌检测实验室记录的回顾性审查.
分析临床记录以确定复发性CDI (rCDI) 率.
从夏洛特·马克塞克约翰内斯堡学术医院 (CMJAH),泰格伯格医院 (TBH) 和因科西·阿尔伯特·卢图利中央学术医院 (IALCH) 收集的数据.

主要成果:

每10,000个患者日的中位数初级CDI率有所不同:5.3 (CMJAH),1.8 (TBH) 和0.3 (IALCH).
与2019年相比,所有医院在2020年观察到初级CDI率的增加.
每10,000个患者日的中位测试率也显示出显著的差异:39 (CMJAH),14 (TBH) 和4 (IALCH).
复发性CDI (rCDI) 的发生率很低,每100次事件发作中有2到5次.

结论:

在南非医院中,CDI和测试率存在显著差异.
2020年SARS-CoV-2疫情与所有研究中心的CDI率增加有关.
建议在南非医院对医疗保健开始的CDI进行系统监测.

关键词:

非洲非洲非洲艰难的克洛斯特里迪奥病毒流行病学.克洛斯特里迪奥伊德困难感染.克洛斯特里迪奥伊德困难的测试率经常发生的CDI非洲

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