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选择性激光烧结用于打印双层平板电脑.

Laura Andrade Junqueira1, Atabak Ghanizadeh Tabriz1, Vivek Garg2

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概括
此摘要是机器生成的。

选择性激光烧结 (SLS) 允许使用罗斯瓦斯塔丁和乙酸制造双层药片. 这种先进的3D打印方法成功地生产了对齐的多药片,具有可控药物释放特征.

关键词:
通过3D打印打印3D打印.比拉耶尔 (Bilayer) 药片是一片药片.口服固体剂型可以使用.选择性激光烧结是一种选择性的激光烧结.

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科学领域:

  • 制药技术 制药技术 制药技术
  • 增材制造 增材制造 增材制造
  • 材料科学 材料科学 材料科学

背景情况:

  • 选择性激光烧结 (SLS) 是一种具有药品应用潜力的增材制造技术.
  • 开发多种药物输送系统需要精确控制药物释放和药片特性.
  • 传统的药片制造方法在生产复杂的多层配方时可能面临挑战.

研究的目的:

  • 调查SLS用于生产含有罗斯瓦斯塔丁和乙盐酸的双层药片的使用.
  • 优化单体药片的SLS参数,并评估它们对药物溶解,硬度和易碎性的影响.
  • 开发和评估一种新的方法,使用SLS与3D打印外制造对齐的双层平板电脑.

主要方法:

  • 采用不同激光强度的SLS制造了罗苏瓦斯塔丁和酸的单体片.
  • 评估了包括溶解,易碎性和硬度在内的药片特性.
  • 开发了一种使用3D打印外的新SLS方法,从不同的粉末混合物中生产对齐的双层平板.

主要成果:

  • 激光强度的增加导致了更密集的平板芯,提高了硬度,降低了易碎性和更慢的药物释放.
  • 新的SLS方法成功地生产了完全对齐的双层片.
  • 与单体平板相比,将双层平板一起打印对药物溶解的影响很小.

结论:

  • 选择性激光烧结是一种可行的技术,用于制造多材料药物递送系统.
  • 开发的SLS方法允许精确制造具有可调节药物释放的对齐双层药片.
  • 这种方法为创建先进的药物剂量形式提供了一个有希望的途径.