捐赠者/接受者预测心脏质量比率的增加不会导致捐赠者右心室的大
Samantha Weller1, Sarah Li2, Luke Masha3
1Department of Internal Medicine, Oregon Health Science University, Portland, Oregon; Knight Cardiovascular Institute, Oregon Health Science University, Portland, Oregon.
概括
对于肺高血压患者来说,过大造型的供体心脏不会显著增加右心室 (RV) 尺寸. 较高的捐赠者-接受者预测心脏质量比率主要导致左心室 (LV) 更大,挑战目前的移植实践.
科学领域:
- 心脏病学 心脏病学
- 移植手术 移植手术
- 心血管研究研究心血管研究
背景情况:
- 肺高血压 (PH) 压力右心室 (RV),往往导致捐赠心脏过大心脏移植.
- 目前的证据支持PH患者的捐赠心脏过大是不确定的.
- 捐赠者-接受者预测心脏质量 (D/R PHM) 比率对捐赠者心室质量的影响需要进一步调查.
研究的目的:
- 研究D/RPHM比率与捐赠左心室 (LV) 和RV质量的变化之间的关系.
- 分析D / RPHM比率与捐赠者-接受者LV和RV质量的预测差异之间的关联.
主要方法:
- 对心脏移植数据的回顾性分析.
- 预测心脏质量 (D/R PHM) 比例的计算.
- 评估与D/R PHM比率相关的供体LV和RV质量变化.
主要成果:
- 增加的D / RPHM比率对捐赠者RV质量产生了最小的影响.
- 在预测的D/R RV质量差与较高的D/R PHM比率中观察到最小的变化.
- 较高的D/R PHM比率与预测的D/R LV质量差异的增加有显著的关联.
结论:
- 使用具有高D/RPHM比率的捐赠者并不总是为移植受体提供更大的RV.
- 高D/RPHM比率的主要影响是提供更大的LV,而不是RV.
- 研究结果表明,需要根据预测的心脏质量比重重新评估捐赠者心脏超大规模的做法.
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