糖尿病前期的患病率根据睡眠呼吸暂停状态
Yoo Jin Um1, Ho Kim2, Joohon Sung2
1Department of Family Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Gyeonggi-do, South Korea.
Primary care diabetes
|December 22, 2024
概括
通过STOP-Bang问卷识别的阻塞性睡眠呼吸暂停 (OSA) 风险与韩国成年人的糖尿病前期有关. 这种关联在绝经后的妇女中特别强烈,突出显示了显著的相关性.
科学领域:
- 内分泌学和新陈代谢学
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种普遍存在的睡眠障碍,人们越来越认识到其对全身健康的影响.
- 糖尿病前期,是2型糖尿病的前体,影响了大部分成年人群,并与心血管风险有关.
- 通过STOP-Bang问卷评估的OSA与糖尿病前期之间的关系尚未在亚洲人群中得到广泛研究.
研究的目的:
- 根据韩国成年人患阻塞性睡眠呼吸暂停 (OSA) 的风险,调查糖尿病前期的患病率.
- 确定通过STOP-Bang得分显示的较高OSA风险与糖尿病前期存在之间的关联.
- 探索OSA-糖尿病前期关联的潜在性别特异性差异,重点关注绝经后妇女.
主要方法:
- 一项横截面研究利用了来自2019-2021年韩国国家健康和营养检查调查的10,131名未被诊断为糖尿病的韩国成年人的数据.
- 使用禁食血糖 (FBG) 和HbA1c标准来定义糖尿病前期,包括基于FBG单独,HbA1c单独或两者的定义.
- 用多变量逻辑回归分析计算了与STOP-Bang分数为3或更高的糖尿病前期相关的几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 共有3,828名参与者 (37.8%) 报告STOP-Bang得分≥3,表明OSA的风险增加.
- 停顿得分≥3与FBG和HbA1c标准 (OR1.06;95% CI1.01-1.12) 定义的糖尿病前期显著相关.
- 这种关联在女性中更为明显,特别是绝经后的女性,她们的糖尿病前期与增加的OSA风险 (OR 1.20-1.21) 的几率明显更高.
结论:
- 这项研究表明,在韩国普通人群中,阻塞性睡眠呼吸暂停的更高风险和糖尿病前期的存在之间存在显著的相关性.
- 这些发现强调了绝经后妇女之间特别强烈的关联,这表明这个子组可能会从针对性查中受益,包括OSA和糖尿病前期.
- 在OSA查的背景下,STOP-Bang问卷可以作为一种有价值的工具,用于识别患有糖尿病前期风险增加的个体.
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