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多功能饮食方法减少肠道炎症与肠道微生物组合的变化有关心脏代谢风险的受试者:SINFONI项目
Hugo Hornero-Ramirez1,2, Arianne Morisette3,4,5, Bruno Marcotte3,4,5
1Centre de Recherche en Nutrition Humaine - Rhône-Alpes, INSERM, INRAe, Université Claude Bernard Lyon1, Hospices Civils de Lyon, Pierre Bénite, France.
Gut microbes
|December 22, 2024
概括
一个多功能营养策略减少了肠道炎症和改变了心脏代谢风险的个体的肠道微生物群. 这种方法通过多个途径准低级炎症,显示出疾病预防的前景.
科学领域:
- 营养科学 营养科学
- 微生物学 微生物学
- 心血管健康 心血管健康
背景情况:
- 心脏代谢性疾病与慢性炎症,肠道失调和肠道完整性降低有关.
- 一个多功能营养策略可以提供一个多目标的方法来缓解这些因素.
研究的目的:
- 研究多功能 (MF) 营养策略对炎症,肠道微生物群 (GM) 和心脏代谢 (CM) 概况的影响.
- 评估MF谷物产品与生物活性化合物和对照产品对CM风险个体的影响.
主要方法:
- 随机交叉对照研究,对30名CM风险受试者进行了2个月的随机交叉对照研究.
- 多粉产品含有多,纤维,缓慢消化的粉和omega-3脂肪酸.
- 评估了代谢性内毒素,全身和肠道炎症,CM标志物,转基因成分和代谢学.
主要成果:
- 干预MF显著减少了肠道炎症 (便calprotectin) 和内毒素 (禁食LPS).
- 多菌干预改变了肠道微生物群的组成,增加了像B. ovatus和B. uniformis这样的有益细菌.
- 没有观察到系统性炎症或整体CM标志物的显著变化.
结论:
- 2个月的饮食干预,结合多种生物活性化合物,有效改善了肠道炎症,并调节了肠道微生物群.
- 这种多目标营养策略显示出管理与心脏代谢风险相关的低级炎症的潜力.
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