高linc01116表达可能会导致各种癌症的预后不佳,基于系统性审查和元分析
Si-Tong Fan1, Dan Li2, Qun-Xian Zhang3
1Department of Infectious Disease, Beilun District People's Hospital of Ningbo, Ningbo City, China.
BMC cancer
|December 22, 2024
概括
长非编码RNA 01116 (linc01116) 的高表达与癌症预后不佳有关,包括整体存活率降低和无进展存活率. 这表明linc01116是癌症结局的潜在生物标志物.
科学领域:
- 分子瘤学分子瘤学
- 癌症基因组学 癌症基因组学
- 生物标志物发现发现
背景情况:
- 长非编码RNA 01116 (linc01116) 在各种癌症中经常受到失调.
- 它的表达水平与患者的预后有关.
研究的目的:
- 通过元分析,研究linc01116表达与癌症预后之间的相关性.
- 评估linc01116作为癌症潜在的预后生物标志物.
主要方法:
- 在六个电子数据库中进行了系统的文献搜索.
- 来自12项涉及809名患者的研究数据进行了元分析,重点关注生存结果和临床参数.
- 统计分析包括将危险比率 (HRs) 和几率比率 (ORs) 与95%置信区间 (CI) 结合在一起,以及敏感性和出版偏差评估.
主要成果:
- 较高的linc01116表达与较低的整体存活率 (HR = 2.096),无进展存活率 (HR = 1.931),和无疾病存活率 (HR = 2.067) 显著相关.
- linc01116的上调也与高级TNM阶段和较差的组织学等级有关.
- 在linc01116表达和淋巴结转移,远程转移,瘤大小或患者人口统计数据之间没有发现显著的关联.
结论:
- linc01116在大多数癌症中是上调调节的,并且与不良的患者预后有关.
- linc01116显示出作为治疗点和各种癌症可靠的预后生物标志物的潜力.
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