基于风险模型和风险因素的低剂量计算机断层扫描查策略对肺癌的益处,危害和成本效益:系统性审查
Yin Liu1, Qingchao Geng1, Xin Lin1
1Department of Cancer Epidemiology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 45008, China.
BMC cancer
|December 22, 2024
概括
基于风险模型的肺癌查提供了比传统方法更高的灵敏度和更少的伤害. 需要进一步的研究来优化风险值和性别特异性标准,以提高效率和成本效益.
科学领域:
- 肺部医学 肺部医学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 肺癌查策略正在发展.
- 基于风险因素的方法是传统的,但基于风险模型的策略正在成为替代方案.
- 需要进行系统审查来比较这些策略.
研究的目的:
- 审查基于风险模型的肺癌查与基于风险因素的肺癌查的益处,危害和成本效益.
- 讨论未来的肺癌查研究方向.
主要方法:
- 从1994年到2024年,在主要数据库 (PubMed, Web of Science, Cochrane, EMBASE) 中按照PRISMA指南进行了全面的文献搜索.
- 包括的研究比较了基于风险模型和基于风险因素的低剂量计算机断层扫描 (LDCT) 查肺癌.
- 提取的数据包括查标准和结果,如敏感性,特异性,死亡率降低和成本效益.
主要成果:
- 基于风险模型的策略显示出比基于风险因素的策略更高的灵敏度和更低的辐射相关伤害.
- 获得寿命年数和避免肺癌死亡等结果各不相同,表明需要最佳风险值的确定.
- 基于风险模型的策略显示出更高的成本效益的潜力,特别是在个性化时,女性的净收益更高.
结论:
- 基于风险模型的LDCT查对肺癌检测更为敏感,并可能更有效.
- 未来的研究应该专注于最佳风险值,性别特异性标准和个体风险因素动态,以获得更广泛的适用性.
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