喘成年人中的铜摄入量和死亡率:一项队列研究
Linlin Huang1, Hegan Zhang2, Rongjuan Zhuang3
1Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China.
Biological trace element research
|December 22, 2024
概括
饮食中较高的铜摄入量与患有喘的成年人死亡风险较低有关. 这一发现表明,增加铜消费可能会改善喘患者的长期存活率.
科学领域:
- 营养流行病学 营养流行病学
- 呼吸系统医学 呼吸系统医学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 微量矿物质失衡与氧化应激,炎症和喘中的免疫失调有关.
- 关于铜摄入量与喘患者死亡风险之间的具体关系的研究有限.
研究的目的:
- 研究饮食中的铜摄入量与被诊断患有喘的个体的死亡率之间的关联.
- 探索铜消费对喘患者生存的影响.
主要方法:
- 分析了来自全国健康和营养检查调查 (NHANES) 3175 名参与者的数据.
- 利用多种统计模型,包括考克斯的比例危险模型,趋势测试,限制立方线 (RCS),值效应模型和CoxBoost模型.
- 卡普兰-梅尔分析被用来根据铜摄入水平来比较生存率.
主要成果:
- 三种Cox危险模型显示,铜摄入量与喘患者死亡风险之间存在反向关系.
- 趋势测试,RCS模型和值效应模型证实了饮食中的铜与死亡风险之间的线性反向关联.
- 较高的铜摄入量与喘成年人的生存率增加相关,而铁摄入量与较高的死亡风险有关.
结论:
- 饮食中的铜摄入量与喘患者的死亡风险之间存在显著的反向和线性相关性.
- 足够的铜摄入量可能对喘患者的长期存活和预后有积极的影响.
- 铜,和摄入量显示对死亡率有保护作用,与铁与增加风险的关联形成鲜明对比.
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