泰莫西林对产生AmpCβ-乳糖酶的肠道细菌的疗效:一种与塞菲皮姆相关的替代品?
Xavier Brousse1,2, Fanny Andry2, Marin Lahouati3
1Infectious Diseases Unit, CHU de Bordeaux, Bordeaux, F-33000, France.
The Journal of antimicrobial chemotherapy
|December 23, 2024
概括
泰莫西林在治疗由AmpCβ-lactamase产生肠道细菌 (ABPE) 引起的感染方面表现出高度的敏感性和成功率. 这项研究表明,泰莫西林是治疗ABPE感染的可行替代品.
科学领域:
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
- 临床药理学 临床药理学
背景情况:
- 泰莫西林是一种β-lactam抗生素,对AmpCβ-lactamases具有稳定性.
- 对Temocillin用于AMPCβ-乳糖酶产生肠杆菌 (ABPE) 感染的临床数据有限.
- 目前的指导方针并不广泛推泰莫西林用于治疗ABPE.
研究的目的:
- 为了确定ABPE分离物对泰莫西林的敏感性.
- 为了评估用泰莫西林治疗ABPE感染的患者的临床结果.
主要方法:
- 追溯性,多中心研究,分析抗微生物敏感性测试 (AST) 数据和患者临床记录.
- 从2021年5月到2023年8月的ABPE分离物被评估为泰莫西林敏感性.
- 在2017年至2023年期间接受泰莫西林治疗ABPE感染的患者的治疗结果被分析.
主要成果:
- 在5166个ABPE菌株中,82%对泰莫西林敏感.
- 在第三代抗素 (3GCR) 的ABPE菌株中,66%对泰莫西林敏感,59%对塞费皮姆敏感.
- 在63名用泰莫西林治疗ABPE感染的患者中,观察到89%的治疗成功率,包括复杂的尿路和骨/关节感染.
结论:
- 泰莫西林在治疗ABPE感染方面显示出可靠性和高的治疗成功率.
- 它的良好的耐受性,狭窄的光谱和易于施用,使得泰莫西林成为Cefepime的潜在替代品.
- 进一步的研究可能会支持将泰莫西林纳入ABPE感染治疗指南.
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