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Updated: Jun 4, 2025

Visualization of G3BP Stress Granules Dynamics in Live Primary Cells
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Visualization of G3BP Stress Granules Dynamics in Live Primary Cells

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G3BP1/2-向PROTAC 干扰压力颗粒 作为癌症治疗的ATF4迁移细胞

Ting Dong1,2, Fabao Zhao3, Mengmeng Wang2

  • 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 2A Nanwei Road, Xicheng District, Beijing 100050, China.

Journal of the American Chemical Society
|December 23, 2024
PubMed
概括

针对压力颗粒 (SGs) 的新化合物通过阻止ATF4生存因子从纤维细胞转移到瘤细胞来抑制癌症生长. 这一发现为癌症治疗提供了新的治疗策略.

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