施万细胞分泌的S100B通过对膜调节促进伤口愈合
1Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
Journal of dental research
|December 23, 2024
概括
施万细胞对于口腔粘膜伤口愈合至关重要,分泌S100B蛋白,通过特定的信号通路加速组织修复. 这一发现为伤口愈合治疗提供了新的治疗见解.
科学领域:
- 再生医学是一种再生医学.
- 细胞生物学 细胞生物学
- 组织工程是组织工程.
背景情况:
- 口腔组织表现出显著的再生能力,对牙移植至关重要,但潜在的机制尚不清楚.
- 众所周知,施万细胞在各种组织中参与伤口修复,这表明它们在粘膜愈合中可能发挥作用.
研究的目的:
- 研究施万细胞在口腔粘膜的伤口愈合过程中的作用.
- 阐明 Schwann 细胞为 palatal 伤口再生做出贡献的特定分子机制.
主要方法:
- 在非人类灵长类动物中进行多组学分析 (scRNA-seq和蛋白质组学).
- 在口腔粘膜,口腔附着牙和皮肤中开发伤口愈合模型.
- 在鼠和子皮肤模型中使用GelMA水凝进行体内验证.
主要成果:
- 与其他组织相比,口腔粘膜在基线显示了施万细胞的较高分布和较低分化.
- 在口腔伤口愈合期间观察到S100B水平升高.
- 施万细胞分泌的S100B通过S100B/RAGE轴促进纤维细胞活性,激活NF-κB和Notch信号,以更快地关闭伤口.
结论:
- 施万细胞通过S100B/RAGE/NF-κB/Notch对膜信号轴在口腔粘膜伤口愈合中发挥着至关重要的作用.
- 蛋白质S100B证明了增强伤口愈合的治疗潜力.
- 这项研究为口腔组织的再生能力提供了新的见解,并确定了关键的细胞参与者和涉及的途径.
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