西方饮食对阴功能和健康的有害影响是可逆的
Sarah Carpinelli1, John Ahlert1, Maxwell Rubin1
1Arizona College of Osteopathic Medicine, Midwestern University, Glendale, Arizona, United States.
American journal of physiology. Gastrointestinal and liver physiology
|December 23, 2024
概括
高脂肪,高糖 (西方) 饮食会损害肠道分泌功能,但这种影响是可逆的. 切换到标准饮食恢复了小鼠的正常内功能,这表明了与肥胖相关的胃肠道问题的潜在治疗策略.
科学领域:
- 胃肠病学和肝病学
- 营养科学 营养科学
- 生理学 生理学 生理学
背景情况:
- 西方饮食的特点是高脂肪和高糖含量,与许多健康问题有关,包括胃肠道障碍.
- 了解饮食引起的肠道功能障碍的可逆性对于开发有效的肥胖干预措施至关重要.
研究的目的:
- 调查高脂肪,高糖饮食对肠道功能和健康的负面影响是否可逆.
- 为了确定底层的特定机制,饮食诱导的变化在关功能.
主要方法:
- 雄性C57Bl/6J小鼠在24周内接受高脂肪,高糖饮食 (HFHS) 或标准食.
- 一个单独的组被食HFHS饮食12周,随后是标准饮食12周 (Std).
- 评估了体短路电流 (Isc),骨形态,蛋白质表达 (包括ClC2,TNF-α,MPO) 和血清/组织标记物.
主要成果:
- 与对照组相比,HFHS养的小鼠的基底脊髓Isc显著降低,这表明分泌功能受损.
- 切换到标准饮食完全逆转了Isc.的下降.
- 减少Isc与激活化通道 (ClC2) 的表达减少有关.
结论:
- 西方饮食引起的基底内分泌功能受损,在恢复标准饮食后可逆.
- 这些发现突出了饮食干预措施的潜力,以减轻或逆转肥胖中与西方饮食相关的胃肠道异常.
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