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Updated: Jun 4, 2025

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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泛KRAS抑制剂BI-2493和BI-2865在具有KRAS野生类型等位基扩增的瘤中显示出强大的抗瘤活性

Antonio Tedeschi1, Fiorella Schischlik1, Francesca Rocchetti1

  • 1Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.

Molecular cancer therapeutics
|December 23, 2024
PubMed
概括

新的泛KRAS抑制剂,BI-2493和BI-2865,在临床前模型中显示出强大的抗瘤活性. KRAS野生型 (WT) 放大瘤对这些"关闭"状态抑制剂特别敏感,提供了一种新的治疗策略.

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