基于连接组的症状映射和与自闭症和/或注意力缺陷/多动症障碍儿童的基因相关的基因表达
Patricia Segura1,2, Marco Pagani1,3,4, Somer L Bishop5
1Child Mind Institute, New York, NY, USA.
medRxiv : the preprint server for health sciences
|December 23, 2024
概括
自闭症和多动症有着共同的生物学联系,与儿童自闭症严重程度相关的特定大脑区域之间更大的功能连接. 共同的遗传因素可能是这些重叠症状的基础.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 儿童精神病学 儿童精神病学
背景情况:
- 自闭症谱系障碍 (ASD) 和注意力缺陷/多动性障碍 (ADHD) 具有显著的临床重叠.
- 越来越多的证据表明,ASD和ADHD之间存在共同的神经生物学基础.
研究的目的:
- 调查ASD和ADHD核心症状严重程度与内在功能连接 (iFC) 之间的关系.
- 探索在ASD和ADHD儿童中观察到的大脑行为关联的共同遗传机制.
主要方法:
- 利用全脑多变量距离矩阵回归来分析ASD或ADHD的166名儿童 (6-12岁) 的IFC.
- 检查了尺寸症状测量和全脑iFC之间的关联,以及在基因表达模式分析.
主要成果:
- 发现了自闭症症状严重程度和中额头 (前侧双侧网络) 和后侧带带皮层 (默认模式网络) 之间的IFC之间的跨诊断关联.
- 这些节点之间的更高的IFC与自闭症严重程度的增加相关,独立于ADHD症状.
- 对于ADHD症状,没有发现显著的脑行为关系.
- 基因分析发现了参与神经元投射的基因,并且已知在ASD和ADHD中存在差异.
结论:
- 这些发现强调了跨诊断方法在理解ASD和ADHD之间共享生物学方面的相关性.
- 内在功能连接的特定模式和相关的遗传因素可能代表一个共享的神经生物学现象型.
- 互联网网络连接对于了解诊断群体中自闭症症状严重程度至关重要.
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