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Updated: Jun 4, 2025

Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses
08:36

Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses

Published on: October 24, 2019

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雄激素受体驱动聚胺合成,为前列腺癌造成脆弱性

Rajendra Kumar, Sheila Jonnatan, David E Sanin

    medRxiv : the preprint server for health sciences
    |December 23, 2024
    PubMed
    概括

    超生理性雄激素 (SPA) 通过激活雄激素受体 (AR) 来调节ODC1.1,从而促进前列腺癌中的聚胺合成. 抑制聚胺合成增强了SPA的有效性,揭示了治疗的脆弱性.

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